Laboratório de Cromatografia, Departamento de Química, Universidade Federal do Amazonas, Manaus, AM, Brasil.
Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:142-58. doi: 10.1590/s0074-02762011000900019.
The isolation of bioactive compounds from medicinal plants, based on traditional use or ethnomedical data, is a highly promising potential approach for identifying new and effective antimalarial drug candidates. The purpose of this review was to create a compilation of the phytochemical studies on medicinal plants used to treat malaria in traditional medicine from the Community of Portuguese-Speaking Countries (CPSC): Angola, Brazil, Cape Verde, Guinea-Bissau, Mozambique and São Tomé and Príncipe. In addition, this review aimed to show that there are several medicinal plants popularly used in these countries for which few scientific studies are available. The primary approach compared the antimalarial activity of native species used in each country with its extracts, fractions and isolated substances. In this context, data shown here could be a tool to help researchers from these regions establish a scientific and technical network on the subject for the CPSC where malaria is a public health problem.
从药用植物中分离具有生物活性的化合物，基于传统用途或民族医学数据，是一种极具前景的潜在方法，可以确定新的、有效的抗疟药物候选物。本综述的目的是汇编用于治疗葡萄牙语国家共同体（CPLP）国家疟疾的药用植物的植物化学研究：安哥拉、巴西、佛得角、几内亚比绍、莫桑比克和圣多美和普林西比。此外，本综述旨在表明，有几种在这些国家流行用于治疗疟疾的药用植物，针对这些植物的科学研究很少。主要方法是比较每个国家使用的本土物种的抗疟活性与其提取物、馏分和分离物质。在这种情况下，这里显示的数据可以作为帮助来自这些地区的研究人员在 CPLP 中建立一个关于疟疾的科学和技术网络的工具，因为疟疾是一个公共卫生问题。
