Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.
Jpn J Radiol. 2011 Aug;29(7):503-12. doi: 10.1007/s11604-011-0588-4. Epub 2011 Sep 1.
The aim of this study was to assess the mechanism of the protective effect of hydrogen-rich water (HW) against cisplatin (CP)-induced nephrotoxicity in rats using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI).
Apparent transverse relaxation time-weighted images (T2 WI) were acquired in 28 rats. The control group (n = 7) had free access to standard water (SW) and no CP injection. The CP group (n = 7) had free access to SW and was given a CP injection on day 0. The CP+HW group (n = 7) had free access to HW and had a CP injection. The HW group (n = 7) had free access to HW and no CP injection. The apparent transverse relaxation rate (R2) was estimated from T2 WI.
In the CP+HW group, the R2 value in the medulla normalized by the value of the day 0 was significantly greater than that in the CP group on days 4 and 7. The creatinine and blood urea nitrogen levels in the CP group were significantly higher than those in the control, CP+HW, and HW groups.
BOLD MRI may be useful for demonstrating the change in R2 in CP-induced nephrotoxicity in rats. The changes in the CP+HW group were suspected to be due to a reduction of cytotoxic oxygen radicals.
本研究旨在利用血氧水平依赖（BOLD）磁共振成像（MRI）评估富氢水（HW）对顺铂（CP）诱导的大鼠肾毒性的保护作用机制。
对 28 只大鼠进行了表观横向弛豫时间加权成像（T2 WI）采集。对照组（n=7）自由饮用标准水（SW）且不注射 CP。CP 组（n=7）自由饮用 SW 且在第 0 天注射 CP。CP+HW 组（n=7）自由饮用 HW 且注射 CP。HW 组（n=7）自由饮用 HW 且不注射 CP。从 T2 WI 中估算表观横向弛豫率（R2）。
在 CP+HW 组中，与 CP 组相比，第 4 天和第 7 天肾髓质的 R2 值与第 0 天的 R2 值之比在 CP+HW 组中显著增加。CP 组的肌酐和血尿素氮水平明显高于对照组、CP+HW 组和 HW 组。
BOLD MRI 可能有助于显示 CP 诱导的大鼠肾毒性中 R2 的变化。CP+HW 组的变化可能归因于细胞毒性氧自由基的减少。
