区域选择性铜介导的噻吩并[2,3-c]吡喃-7-酮、吲哚并[2,3-c]吡喃-1-酮和吲哚并[3,2-c]吡喃-1-酮的合成。
Regioselective copper-mediated synthesis of thieno[2,3-c]pyrane-7-one, indolo[2,3-c]pyrane-1-one, and indolo[3,2-c]pyrane-1-one.
机构信息
Laboratoire de Physicochimie des Matériaux et des Biomolécules, EA 4244, Faculté des Sciences et Techniques de Tours, Parc de Grandmont, 37200 Tours, France.
出版信息
J Org Chem. 2011 Oct 21;76(20):8347-54. doi: 10.1021/jo201528u. Epub 2011 Sep 15.
PMID:21882812
Abstract
In the presence of copper(I) iodide, heteroaromatic β-iodo-α,β-unsaturated carboxylic acid systems opposed to terminal alkyne afford selectively 6-endo-dig cyclization products via a tandem coupling oxacyclization reaction.
摘要
在碘化亚铜存在的情况下，杂芳基β-碘代-α,β-不饱和羧酸体系与末端炔烃反应，通过串联偶联环氧化反应选择性地生成 6-endo-dig 环化产物。
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