Sahu Satya Narayan, Shaw Ranjay, Yadav Saroj, Althagafi Ismail, Upadhyay Manmohan Krishna, Pratap Ramendra
Department of Chemistry, Swami Atmanand Govt. English Medium Model College Ambikapur Surguja Chhattisgarh 497001 India.
Department of Chemistry, GLA University Chaumuhan Uttar Pradesh 281406 India.
RSC Adv. 2025 Apr 17;15(16):12117-12124. doi: 10.1039/d5ra01296a. eCollection 2025 Apr 16.
An efficient, one-pot, and green synthetic strategy was established for 3-amino/hydroxy thieno[3,2-]pyrans in water through a reaction of 6-aryl-4-(methylthio)-2-oxo-2-pyran-3-carbonitriles/carboxylates with methyl thioglycolate, yielding excellent results (65-95%). The present approach was also employed to synthesize benzo[]thieno[3,2-]chromene-2-carboxylate derivatives in good yield. This efficient method eliminated the need for tedious purification steps, and the products were purified by simply washing the crude material with lukewarm water. Furthermore, the reaction medium was reusable and could be repeated up to six cycles, producing the desired product with only minimal loss, although the reaction time increased with each cycle. All the synthesized compounds were characterized by spectroscopic analysis, and the structure of one compound was confirmed by single-crystal X-ray analysis.
通过6-芳基-4-(甲硫基)-2-氧代-2-吡喃-3-腈/羧酸盐与巯基乙酸甲酯的反应，在水中为3-氨基/羟基噻吩并[3,2 -]吡喃建立了一种高效、一锅法且绿色的合成策略，产率优异(65 - 95%)。本方法还用于以良好的产率合成苯并[]噻吩并[3,2 -]色烯-2-羧酸盐衍生物。这种高效的方法无需繁琐的纯化步骤，产物只需用温水洗涤粗产物即可纯化。此外，反应介质可重复使用，最多可重复六个循环，尽管反应时间随每个循环增加，但仅产生极小的损失就能得到所需产物。所有合成的化合物均通过光谱分析进行表征，其中一个化合物的结构通过单晶X射线分析得到证实。
