Cellartis AB, Maclagan House, 1 Wurzburg Court, Medipark, Dundee DD2 1FB, UK.
Future Med Chem. 2011 Sep;3(12):1539-49. doi: 10.4155/fmc.11.98.
Pluripotent stem cells promise to revolutionize drug discovery and offer new modes of therapy. The ease with which they can be grown in bulk and their differentiation controlled in vitro is of importance for their widespread adoption by industry and their clinical efficacy. Small molecules have already had a positive impact on several areas of stem cell biology, from maintenance of pluripotency, the promotion of single cell survival and steering differentiation to involvement in reprogramming somatic cells. High-throughput technology has played an important role in identifying novel compounds, however to date there are few published examples of medicinal chemistry input in this area. This review discusses the potential of pluripotent stem cells, the successful uses of small molecules and future prospects.
多能干细胞有望彻底改变药物发现，并为新的治疗模式提供可能。由于这些细胞在体外大量培养和分化控制方面的便利性，它们被工业界广泛采用，并具有临床疗效。小分子已经对干细胞生物学的几个领域产生了积极影响，包括维持多能性、促进单细胞存活和指导分化，以及参与体细胞重编程。高通量技术在鉴定新化合物方面发挥了重要作用，然而迄今为止，在该领域很少有关于药物化学投入的文献报道。本文综述了多能干细胞的潜力、小分子的成功应用以及未来前景。
