Department of Prosthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Gerodontology. 2012 Jun;29(2):e715-20. doi: 10.1111/j.1741-2358.2011.00549.x. Epub 2011 Aug 24.
The efficacy of a topical gel with triester glycerol oxide for treating ulcerations related to new complete dentures was studied and compared with a placebo gel.
Fifty edentulous patients were enrolled in this double-blind clinical study. All subjects received new maxillary and mandibular complete dentures and were recalled 1, 3 and 7 days after denture placement. Twenty-five subjects received topical gel with triester glycerol oxide (TGO), and 25 subjects received topical gel without TGO. At each visit, pain and discomfort with the new dentures was assessed, and at the last visit, healing of ulcerations was also graded by a clinician. Subjects also graded the gel's taste, smell and ease of use.
Specifically, there was no statistically significant difference in ulcer healing (p > 0.05), ratings of smell, taste and ease of use (p > 0.05) or pain and discomfort scores (p > 0.05). However, within-group differences were observed in pain and discomfort scores between follow-up sessions (p = 0.01 for all comparisons).
Clinically, TGO gel is not effective in the treatment of mucosal injuries occurring following placement of complete dentures.
研究并比较三酯基甘油氧化物（TGO）局部凝胶治疗全口义齿相关溃疡的疗效。
本双盲临床研究纳入了 50 名无牙颌患者。所有患者均接受了上颌和下颌新全口义齿，并在义齿佩戴后 1、3 和 7 天进行了随访。25 名患者接受了含有 TGO 的局部凝胶治疗，25 名患者接受了不含 TGO 的局部凝胶治疗。每次就诊时，评估新义齿引起的疼痛和不适，最后一次就诊时，临床医生还对溃疡的愈合情况进行了分级。患者还对凝胶的口感、气味和使用便利性进行了评分。
具体来说，溃疡愈合情况（p＞0.05）、气味、口感和使用便利性评分（p＞0.05）或疼痛和不适评分（p＞0.05）均无统计学差异。然而，在各次随访中，疼痛和不适评分在组内存在差异（所有比较均为 p=0.01）。
临床研究表明，TGO 凝胶对于治疗全口义齿佩戴后发生的黏膜损伤无效。
