Department of Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
Dermatol Surg. 2011 Dec;37(12):1721-9. doi: 10.1111/j.1524-4725.2011.02123.x. Epub 2011 Aug 24.
Treatments for alopecia are in high demand, but not all are safe and reliable. Dalteparin and protamine microparticles (D/P MPs) can effectively carry growth factors (GFs) in platelet-rich plasma (PRP).
To identify the effects of PRP-containing D/P MPs (PRP&D/P MPs) on hair growth.
METHODS & MATERIALS: Participants were 26 volunteers with thin hair who received five local treatments of 3 mL of PRP&D/P MPs (13 participants) or PRP and saline (control, 13 participants) at 2- to 3-week intervals and were evaluated for 12 weeks. Injected areas comprised frontal or parietal sites with lanugo-like hair. Experimental and control areas were photographed. Consenting participants underwent biopsies for histologic examination.
D/P MPs bind to various GFs contained in PRP. Significant differences were seen in hair cross-section but not in hair numbers in PRP and PRP&D/P MP injections. The addition of D/P MPs to PRP resulted in significant stimulation in hair cross-section. Microscopic findings showed thickened epithelium, proliferation of collagen fibers and fibroblasts, and increased vessels around follicles.
PRP&D/P MPs and PRP facilitated hair growth but D/P MPs provided additional hair growth. The authors have indicated no significant interest with commercial supporters.
脱发的治疗需求很高，但并非所有治疗方法都安全可靠。达肝素和鱼精蛋白微粒（D/P MPs）可有效携带富含血小板的血浆（PRP）中的生长因子（GFs）。
确定含有 PRP 的 D/P MPs（PRP&D/P MPs）对毛发生长的影响。
26 名头发稀疏的志愿者参与了这项研究，他们在 2-3 周的间隔内接受了 5 次局部治疗，每次 3 毫升的 PRP&D/P MPs（13 名参与者）或 PRP 和生理盐水（对照组，13 名参与者），并在 12 周内进行评估。注射区域包括有毫毛样毛发的额部或顶部分区。对实验区和对照区进行拍照。同意参与的参与者接受活检以进行组织学检查。
D/P MPs 可与 PRP 中包含的各种 GFs 结合。在 PRP 和 PRP&D/P MPs 注射中，头发横截面积有显著差异，但头发数量没有差异。在 PRP 中添加 D/P MPs 可显著刺激头发横截面积的增加。显微镜检查结果显示上皮增厚、胶原纤维和成纤维细胞增殖以及毛囊周围血管增加。
PRP&D/P MPs 和 PRP 促进毛发生长，但 D/P MPs 提供了额外的毛发生长。作者表示没有与商业支持者的重大利益关系。
