Florida State University College of Medicine, Tallahassee, FL 32114, USA.
J Sex Med. 2011 Nov;8(11):3193-5. doi: 10.1111/j.1743-6109.2011.02440.x. Epub 2011 Aug 24.
Priapism is a common concern in sickle cell disease. With a high frequency of recurrences and serious long-term sequela, a preventative, rather than traditionally reactive approach, needs to be taken in these patients. Reports have shown successful use of sildenafil as a prophylactic treatment but have failed to address adverse outcomes, including vasoocclusive pain crises, of chronic sildenafil therapy in sickle cell patients.
We wish to draw attention to the potential adverse outcomes of this therapy on the overall state of the patient's disease for consideration in future studies.
We used sildenafil in a patient suffering from almost daily attacks of priapism.
Sildenafil was successful in decreasing the frequency of priapism; however, our patient experienced an increased frequency of vasoocclusive crises, something not previously addressed.
Future studies of sildenafil use in sickle cell disease need to assess the global state of the disease, not just the frequency of priapism.
镰状细胞病中常发生阴茎异常勃起。由于反复发作且存在严重的长期后果，因此需要对这些患者采取预防措施，而不是传统的对症治疗方法。有报道显示西地那非可成功用于预防性治疗，但并未解决慢性西地那非治疗镰状细胞病患者的不良结局，包括血管阻塞性疼痛危象。
我们希望引起人们对这种治疗方法对患者整体疾病状况的潜在不良后果的关注，以供未来研究考虑。
我们使用西地那非治疗一名几乎每天都发生阴茎异常勃起的患者。
西地那非成功降低了阴茎异常勃起的频率；然而，我们的患者经历了血管阻塞性危象的频率增加，这是以前未曾报道过的。
未来关于镰状细胞病中西地那非使用的研究需要评估疾病的整体状况，而不仅仅是阴茎异常勃起的频率。
