Anele Uzoma A, Morrison Belinda F, Burnett Arthur L
Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-2101, USA.
Curr Drug Targets. 2015;16(5):474-83. doi: 10.2174/1389450115666141111111842.
Priapism is an erectile disorder involving uncontrolled, prolonged penile erection without sexual purpose, which can lead to erectile dysfunction. Ischemic priapism, the most common of the variants, occurs with high prevalence in patients with sickle cell disease. Despite the potentially devastating complications of this condition, management of recurrent priapism episodes historically has commonly involved reactive treatments rather than preventative strategies. Recently, increasing elucidation of the complex molecular mechanisms underlying this disorder, principally involving dysregulation of nitric oxide signaling, has allowed for greater insights and exploration into potential therapeutic targets. In this review, we discuss the multiple molecular regulatory pathways implicated in the pathophysiology of priapism. We also identify the roles and mechanisms of molecular effectors in providing the basis for potential future therapies.
阴茎异常勃起是一种勃起功能障碍，表现为无性欲目的的不受控制的持续性阴茎勃起，可导致勃起功能障碍。缺血性阴茎异常勃起是最常见的一种类型，在镰状细胞病患者中高发。尽管这种疾病可能会引发严重的并发症，但从历史上看，复发性阴茎异常勃起发作的治疗通常是反应性治疗而非预防性策略。最近，对这种疾病潜在的复杂分子机制（主要涉及一氧化氮信号失调）的深入了解，使人们对潜在治疗靶点有了更多认识和探索。在这篇综述中，我们讨论了阴茎异常勃起病理生理学中涉及的多种分子调节途径。我们还确定了分子效应器的作用和机制，为未来潜在的治疗提供依据。
