Ibsen T B, Svendsen U G
ASTRA-Gruppen A/S, Roskildevej.
Ugeskr Laeger. 1990 May 7;152(19):1375-8.
A total of 140 patients with chronic obstructive pulmonary disease was included in this multicentre parallel group investigation with the object of assessing whether poor inhalation technique results in increased consumption of beta 2-agonist. On the basis of measurements of pulmonary function, the patients were stratified into two groups with good and poor inhalation techniques, respectively, and these were subdivided at random to inhalation of terbutaline via either a freon spray (aerosol) or Turbohaler (powder). During a period of four weeks the daily terbutaline consumption, the symptoms and pulmonary function were noted. Patients with poor inhalation technique did not have significantly increased terbutaline consumption. The consumption of terbutaline was independent of the method of administration. The Turbohaler was just as effective as the spray and the patients preferred this method, (p less than 0.05).
本多中心平行组研究共纳入140例慢性阻塞性肺疾病患者，目的是评估吸入技术不佳是否会导致β2激动剂的消耗量增加。根据肺功能测量结果，患者分别被分为吸入技术良好和不佳的两组，并随机再细分为通过氟利昂喷雾剂（气雾剂）或都保（干粉吸入器）吸入特布他林的两组。在四周的时间里，记录每日特布他林的消耗量、症状和肺功能。吸入技术不佳的患者特布他林消耗量并未显著增加。特布他林的消耗量与给药方法无关。都保与喷雾剂同样有效，且患者更喜欢这种方法，（p<0.05）。
