通过 p57 和其伙伴蛋白阻断造血干细胞的细胞周期。
Breaking the cell cycle of HSCs by p57 and friends.
机构信息
Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
出版信息
Cell Stem Cell. 2011 Sep 2;9(3):187-92. doi: 10.1016/j.stem.2011.08.005.
PMID:21885016
Abstract
The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.
摘要
长期以来，参与维持体干细胞静止状态（从而维持其自我更新能力）的细胞周期调控因子一直难以捉摸。本期《细胞—干细胞》中的两篇新文章（Matsumoto 等人，2011；Zou 等人，2011）现在表明，细胞周期蛋白依赖性激酶抑制剂 p57 是循环造血干细胞（HSCs）的关键制动装置，将自我更新活性与细胞周期静止联系起来。
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