Smith C L, Berkseth R O
Regional Kidney Disease Program, Hennepin County Medical Center, Minneapolis, Minn.
Am J Nephrol. 1990;10(1):61-8. doi: 10.1159/000168056.
The erythrocytes from 19 chronic hemodialysis patients were examined for Heinz bodies and their sensitivity to oxidant stress. Heinz bodies were found in 63% of patients and an elevated level of oxidized hemoglobin in 36%. When exposed to acetylphenhydrazine oxidant stress, 84% had a normal response and 95% had stable reduced glutathione levels. Ascorbic-acid-induced oxidant stress was tolerated by 84%. The activities of enzymes associated with the hexose monophosphate shunt were examined and found to be intact. This study demonstrates an increased number of Heinz bodies in hemodialysis patients. However, this is not due to an increased sensitivity to oxidant stress. Other mechanisms must be sought to explain the presence of Heinz bodies in these patients.
对19名慢性血液透析患者的红细胞进行了 Heinz 小体及其对氧化应激敏感性的检查。63% 的患者发现有 Heinz 小体，36% 的患者氧化血红蛋白水平升高。当暴露于乙酰苯肼氧化应激时，84% 的患者反应正常，95% 的患者谷胱甘肽还原水平稳定。84% 的患者能耐受抗坏血酸诱导的氧化应激。对与磷酸己糖旁路相关的酶活性进行了检查，发现其功能正常。本研究表明血液透析患者的 Heinz 小体数量增加。然而，这并非由于对氧化应激的敏感性增加所致。必须寻找其他机制来解释这些患者中 Heinz 小体的存在。
