Service de neurologie, hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125 route de Stalingrad, Bobigny, France.
Rev Neurol (Paris). 2011 Oct;167(10):668-72. doi: 10.1016/j.neurol.2011.07.002. Epub 2011 Aug 31.
Glioblastoma patients spontaneously develop anti-tumour immune responses. However, the tumour itself develops several mechanisms that allow the tumor to escape the immune system. Clinical trials using infusion of activated autologous immune cells, or active immunotherapy with tumor antigens and dendritic cells have successfully induced anti-tumour immunity and some radiological responses. More recently, approaches targeting the mechanisms of tolerance have shown promising data in melanoma, and are currently under investigations in gliomas. However, large randomised trials are still needed to prove the usefulness of cancer vaccines in brain tumors.
胶质母细胞瘤患者会自发产生抗肿瘤免疫反应。然而，肿瘤本身会发展出几种机制，使肿瘤能够逃避免疫系统。使用输注激活的自体免疫细胞或用肿瘤抗原和树突状细胞进行主动免疫疗法的临床试验已成功诱导了抗肿瘤免疫和一些影像学反应。最近，针对耐受机制的方法在黑色素瘤中显示出了有前景的数据，目前正在胶质母细胞瘤中进行研究。然而，仍需要进行大规模的随机试验来证明癌症疫苗在脑肿瘤中的有效性。
