UNESP-Univ. of Estadual Paulista, Araraquara Dental School, Department of Periodontology, Araraquara, São Paulo, Brazil.
Med Hypotheses. 2011 Nov;77(5):905-11. doi: 10.1016/j.mehy.2011.08.008. Epub 2011 Aug 31.
Bisphosphonate-related osteonecrosis of the jaws is a relevant side-effect of these drugs that has been generating a great concern through increasing reports, worldwide, of this bone necrosis. Among several BRONJ hypothetical co-factors that could play a role in BRONJ pathogenesis, rheumatoid arthritis (RA) has been included as a relevant risk factor for BRONJ; however, until now the relationship between these diseases has not been fully explained. Thus, the purpose of this paper is to establish hypothetical factors that could link these two diseases, considering mainly inflammatory components and the organism effects of medicines used to treat RA, particularly steroids and methotrexate (MTX).
颌骨骨坏死是双膦酸盐相关药物的一种相关副作用，由于世界各地对这种骨坏死的报告不断增加，该副作用引起了极大的关注。在可能导致 BRONJ 发病机制的几种 BRONJ 假设共同因素中，类风湿关节炎 (RA) 已被纳入 BRONJ 的相关危险因素；然而，到目前为止，这些疾病之间的关系尚未得到充分解释。因此，本文的目的是确定可能将这两种疾病联系起来的假设因素，主要考虑炎症成分和用于治疗 RA 的药物（特别是类固醇和甲氨蝶呤）对机体的影响。
