Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Department of Medicine and Orofacial Surgery, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain.
Biomed Res Int. 2019 Sep 22;2019:1271492. doi: 10.1155/2019/1271492. eCollection 2019.
This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease.
Thirty C57BL/6N mice were randomly divided into three groups ( = 10). All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed and the mandibles were collected for radiological and histological examinations.
Microcomputed tomography (-CT) examination showed significantly reduced periapical bone resorption in the ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups. Higher bone mineral density (BMD) and strengthened microstructure were found in ZA and ZA/Dx groups. More empty lacunae were found in ZA and ZA/Dx groups.
Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ.
本研究旨在评估唑来膦酸对伴有根尖周病的免疫功能低下小鼠模型的作用。
将 30 只 C57BL/6N 小鼠随机分为三组（每组 10 只）。所有动物均接受双侧卵巢切除术（OVX），然后用生理盐水（Veh）、唑来膦酸（ZA）或唑来膦酸和地塞米松联合治疗（ZA/Dx）12 周。给药开始后 8 周，在下颌第一磨牙的左下进行牙髓暴露。牙髓暴露后 4 周，处死所有小鼠，采集下颌骨进行放射学和组织学检查。
微计算机断层扫描（-CT）检查显示，ZA/Dx 组根尖周骨吸收明显减少，ZA 和 ZA/Dx 组牙周骨吸收减少。ZA 和 ZA/Dx 组的骨矿物质密度（BMD）更高，微结构增强。ZA 和 ZA/Dx 组有空腔。
根尖周病在免疫功能低下的情况下加重 MRONJ。同时使用 ZA 和类固醇抑制牙槽骨吸收，但增加了发生 MRONJ 的风险。
