State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China.
Zoology (Jena). 2011 Oct;114(5):306-12. doi: 10.1016/j.zool.2011.04.002. Epub 2011 Aug 31.
Glucose plays an important role in immunity. Three day fasting will decrease cellular immunity and blood glucose levels in Mongolian gerbils (Meriones unguiculatus). In the present study, we tested the hypothesis that glucose supplement can reverse the fasting-induced suppression in cellular immunity in gerbils. Twenty-eight male gerbils were selected and randomly divided into fed and fasting groups. Half of the gerbils in each group were then provided with either 10% glucose water or pure water. After 66 h, each gerbil was injected with phytohaemagglutinin (PHA) solution to challenge cellular immunity. Results showed that glucose supplement restored blood glucose levels in fasted gerbils to those of the fed controls. It also recovered cellular immunity, body fat mass and serum leptin levels in fasted gerbils to the values of the fed controls. Blood glucose levels were positively correlated with body fat mass, leptin levels and cellular immune responses. Thymus and spleen masses, and white blood cells in fasted gerbils were not affected by glucose supplement. In general, our data demonstrate that glucose supplement could reverse fasting-induced suppression of cellular immunity in Mongolian gerbils.
葡萄糖在免疫中发挥重要作用。三天禁食会降低蒙古沙鼠（Meriones unguiculatus）的细胞免疫和血糖水平。在本研究中，我们检验了补充葡萄糖可以逆转沙鼠禁食引起的细胞免疫抑制的假设。选择 28 只雄性沙鼠并将其随机分为进食组和禁食组。每组中的一半沙鼠随后分别给予 10%葡萄糖水或纯水。66 小时后，每只沙鼠均注射植物血球凝集素（PHA）溶液以挑战细胞免疫。结果表明，葡萄糖补充使禁食沙鼠的血糖水平恢复到进食对照组的水平。它还使禁食沙鼠的细胞免疫、体脂肪量和血清瘦素水平恢复到进食对照组的水平。血糖水平与体脂肪量、瘦素水平和细胞免疫反应呈正相关。葡萄糖补充对禁食沙鼠的胸腺和脾脏质量以及白细胞没有影响。总的来说，我们的数据表明，葡萄糖补充可以逆转蒙古沙鼠禁食引起的细胞免疫抑制。
