包涵体肌炎。
Inclusion body myositis.
机构信息
Division of Neuromuscular Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Curr Opin Rheumatol. 2011 Nov;23(6):574-8. doi: 10.1097/BOR.0b013e32834b53cc.
PURPOSE OF REVIEW
Sporadic inclusion body myositis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle. Here, current opinion of the nature of this disease is summarized.
RECENT FINDINGS
Recent findings for sIBM include further characterization of muscle involvement through magnetic resonance imaging, the role of muscle as a host for immune cells, progress in the role of extranuclear TDP-43 in causing cellular injury, and the discovery of a new sIBM autoantibody.
SUMMARY
sIBM understanding continues to advance, with progress regarding the mechanism of this disease.
目的综述
散发性包涵体肌炎（sIBM）是一种发病机制尚未完全阐明的骨骼肌免疫和退行性疾病。本文总结了目前对该病性质的看法。
最近发现
sIBM 的最新发现包括通过磁共振成像进一步描述肌肉受累情况、肌肉作为免疫细胞宿主的作用、核外 TDP-43 在引起细胞损伤中的作用的研究进展，以及一种新的 sIBM 自身抗体的发现。
总结
sIBM 的认识不断深入，对该病的发病机制也取得了一定的进展。
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