Kuznetsov Andrey V
Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC 27695-7910 USA.
J Biol Phys. 2010 Sep;36(4):385-403. doi: 10.1007/s10867-010-9191-7. Epub 2010 Jun 2.
The purpose of this paper is to develop a method for calculating organelle transport in dendrites with a non-uniform cross-sectional area that depends on the distance from the neuron soma. The model is based on modified Smith-Simmons equations governing molecular motor-assisted organelle transport. The developed method is then applied to simulating organelle transport in branching dendrites with two particular microtubule (MT) orientations reported from experiments. It is found that the rate of organelle transport toward a dendrite's growth cone heavily depends on the MT orientation, and since there is experimental evidence that the MT orientation in a particular region of a dendrite may depend on the dendrite's developmental stage, the obtained results suggest that a rearrangement of the MT structure may depend on the amount of organelles needed at the growth cone.
本文的目的是开发一种方法，用于计算树突中细胞器的运输，该树突具有取决于距神经元胞体距离的非均匀横截面积。该模型基于控制分子马达辅助细胞器运输的修正史密斯 - 西蒙斯方程。然后将所开发的方法应用于模拟具有从实验中报告的两种特定微管（MT）取向的分支树突中的细胞器运输。研究发现，细胞器向树突生长锥的运输速率在很大程度上取决于MT取向，并且由于有实验证据表明树突特定区域的MT取向可能取决于树突的发育阶段，因此所获得的结果表明MT结构的重排可能取决于生长锥所需细胞器的数量。
