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一名儿童骨髓增生异常综合征转化为急性淋巴细胞白血病。

Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia in a child.

作者信息

Gupta Vineeta, Bhatia Baldev

机构信息

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 India.

出版信息

Indian J Hematol Blood Transfus. 2010 Sep;26(3):111-3. doi: 10.1007/s12288-010-0015-5. Epub 2010 Oct 13.

DOI:10.1007/s12288-010-0015-5
PMID:21886397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3002097/
Abstract

Childhood myelodysplastic syndrome (MDS) is an uncommon condition. Unlike adult MDS, pediatric patients have a more progressive course and rapidly transform to acute myeloid leukemia. Evolution to acute lymphoblastic leukemia is extremely rare. We report a 5 year old female child who presented with refractory anemia with excess blasts and transformed into acute lymphoblastic leukemia 4 months after initial diagnosis.

摘要

儿童骨髓增生异常综合征（MDS）是一种罕见的病症。与成人MDS不同，儿科患者的病程更具进展性，且会迅速转化为急性髓系白血病。转化为急性淋巴细胞白血病极为罕见。我们报告了一名5岁女童，她最初表现为伴有过多原始细胞的难治性贫血，并在初次诊断4个月后转化为急性淋巴细胞白血病。

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本文引用的文献

1
Transformation of myelodysplastic syndrome to T-cell acute lymphoblastic leukemia in a young adult.
Pediatr Hematol Oncol. 2009 Mar;26(2):100-2. doi: 10.1080/08880010902754891.
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Myelodysplastic syndrome.骨髓增生异常综合征
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Transformation of childhood MDS-refractory anemia to acute lymphoblastic leukemia.
J Pediatr Hematol Oncol. 2007 Oct;29(10):725-7. doi: 10.1097/MPH.0b013e31814d6959.
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Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia: a case report and review of the literature.骨髓增生异常综合征转化为急性淋巴细胞白血病：一例报告并文献复习
Int J Hematol. 2004 Feb;79(2):147-51. doi: 10.1532/ijh97.03137.
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Primary myelodysplastic syndrome in children: the clinical experience in 33 cases.儿童原发性骨髓增生异常综合征：33例临床经验
Br J Haematol. 1992 Oct;82(2):347-53. doi: 10.1111/j.1365-2141.1992.tb06428.x.