Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Curr Neuropharmacol. 2011 Mar;9(1):176-82. doi: 10.2174/157015911795017335.
There is a growing evidence that serotoninergic systems modulate dopaminergic neurotransmission. We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in a Japanese population. We found ten single nucleotide polymorphisms (SNPs) and two polynucleotide polymorphisms in TPH2 gene exons and exon-intron boundaries. A total of 162 patients and 243 controls were used for the association analysis between these polymorphisms and METH dependence/psychosis. No significant differences were observed in either genotypic or allelic frequencies between METH dependent/psychotic patients and controls. A global test of differentiation among samples based on haplotype frequencies showed no significant association. With respect to latency of psychosis, prognosis of psychosis, and spontaneous relapse, we found no significant association with these SNPs. These results suggest that the TPH2 gene variants may not be a factor in vulnerability to METH dependence/psychosis.
越来越多的证据表明，5-羟色胺能系统调节多巴胺能神经传递。我们分析了脑色氨酸羟化酶 2（TPH2）基因变异与日本人群中甲基苯丙胺（METH）依赖/精神病的相关性，该基因是 5-羟色胺生物合成的限速酶。我们在 TPH2 基因的外显子和外显子-内含子边界发现了 10 个单核苷酸多态性（SNP）和 2 个多核苷酸多态性。共对 162 名患者和 243 名对照进行了这些多态性与 METH 依赖/精神病之间的关联分析。在 METH 依赖/精神病患者和对照组之间，无论是基因型频率还是等位基因频率均无显著差异。基于单体型频率的样本分化全局检验显示无显著相关性。对于精神病潜伏期、精神病预后和自发性复发，我们未发现这些 SNP 与之存在显著关联。这些结果表明，TPH2 基因变异可能不是易感性与 METH 依赖/精神病的因素。
