从辛伐他汀换用普伐他汀后睡眠呼吸暂停情况的改善。
Improvement in sleep apnoea associated with switch from simvastatin to pravastatin.
作者信息
Cham Stephanie, Gill Komaldeep, Koperski Sabrina, Golomb Beatrice Alexandra
机构信息
University of California, San Diego, Department of Medicine, 9500 Gilman Drive, La Jolla, California, 92093-0995, USA.
出版信息
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.05.2009.1875. Epub 2009 Sep 1.
Abstract
Sleep problems have been reported as an adverse effect of statins. In a randomised trial, simvastatin at 20 mg produced significantly worse sleep quality than either placebo or pravastatin 40 mg. A possible relation to sleep apnoea was hypothesised. Here, the case of a 67-year-old man who experienced sleep apnoea on simvastatin 20 mg is presented. Objective nightly testing showed a prompt, marked, sustained and statistically significant improvement in the obstructive apnoea index when the patient switched to pravastatin 20 mg.
摘要
睡眠问题已被报道为他汀类药物的一种不良反应。在一项随机试验中，20毫克的辛伐他汀所产生的睡眠质量明显比安慰剂或40毫克的普伐他汀更差。有人推测这可能与睡眠呼吸暂停有关。在此，报告一例67岁男性在服用20毫克辛伐他汀时出现睡眠呼吸暂停的病例。客观的夜间测试显示，当患者改用20毫克普伐他汀时，阻塞性呼吸暂停指数迅速、显著、持续且在统计学上有显著改善。
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