Cham Stephanie, Gill Komaldeep, Koperski Sabrina, Golomb Beatrice Alexandra
University of California, San Diego, Department of Medicine, 9500 Gilman Drive, La Jolla, California, 92093-0995, USA.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.05.2009.1875. Epub 2009 Sep 1.
Sleep problems have been reported as an adverse effect of statins. In a randomised trial, simvastatin at 20 mg produced significantly worse sleep quality than either placebo or pravastatin 40 mg. A possible relation to sleep apnoea was hypothesised. Here, the case of a 67-year-old man who experienced sleep apnoea on simvastatin 20 mg is presented. Objective nightly testing showed a prompt, marked, sustained and statistically significant improvement in the obstructive apnoea index when the patient switched to pravastatin 20 mg.
睡眠问题已被报道为他汀类药物的一种不良反应。在一项随机试验中，20毫克的辛伐他汀所产生的睡眠质量明显比安慰剂或40毫克的普伐他汀更差。有人推测这可能与睡眠呼吸暂停有关。在此，报告一例67岁男性在服用20毫克辛伐他汀时出现睡眠呼吸暂停的病例。客观的夜间测试显示，当患者改用20毫克普伐他汀时，阻塞性呼吸暂停指数迅速、显著、持续且在统计学上有显著改善。
