Sembrano E, Barthlen G M, Wallace S, Lamm C
Department of Pediatrics and Medicine, Mount Sinai School of Medicine, New York, NY, USA.
Neurology. 1997 Dec;49(6):1714-7. doi: 10.1212/wnl.49.6.1714.
A 23-year-old woman with the mitochondrial encephalomyopathy NARP (neurogenic muscle weakness, ataxia, and retinitis pigmentosa) presented with symptoms of obstructive sleep apnea (OSA). An overnight polysomnogram (PSG) showed apnea, EEG slowing, and a paucity of sleep spindles. The patient had a tracheostomy for OSA, and 5 months later she had normal EEG patterns and marked clinical improvement. We propose that patients with mitochondrial encephalomyopathies should have sleep evaluations if the history suggests OSA.
一名患有线粒体脑肌病NARP（神经源性肌无力、共济失调和色素性视网膜炎）的23岁女性出现阻塞性睡眠呼吸暂停（OSA）症状。整夜多导睡眠图（PSG）显示呼吸暂停、脑电图减慢和睡眠纺锤波缺乏。该患者因OSA行气管切开术，5个月后脑电图模式正常，临床症状明显改善。我们建议，如果线粒体脑肌病患者的病史提示有OSA，应进行睡眠评估。
