Sherlin Herald Justin, Ramalingam Karthikeyan, Natesan Anuja, Ramani Pratibha, Premkumar Priya, Thiruvenkadam Chandrasekar
Department of Oral and Maxillofacial Pathology, College of Dental Surgery, Saveetha University, Chennai, Tamil Nadu, India.
J Dermatol Case Rep. 2010 Dec 19;4(3):38-43. doi: 10.3315/jdcr.2010.1052.
Lichen sclerosus is a chronic muco-cutaneous inflammatory disorder of uncertain etiology. The prevalence of lichen sclerosus affecting only the oral mucosa is extremely rare and only 26 cases with histologically verified oral lichen sclerosus have been reported.
A 60-year-old man was referred to our hospital for complaints of white lesions in the oral cavity, which was otherwise asymptomatic and did not have any cutaneous or anogenital lesions. Clinical examination revealed white patches with reddish areas on the buccal mucosa bilaterally and on the maxillary posterior gingiva. Microscopic analysis of the lesion showed atrophied epithelium with basal cell degeneration, hyalinized connective tissue stroma with minimal chronic inflammatory cell infiltrate. Verhoeff's staining revealed scantiness of elastic fibers in the connective tissue stroma. On the basis of these histological findings, the final diagnosis was given as Lichen Sclerosus. LS is rare in the oral cavity, particularly in the absence of simultaneous cutaneous and anogenital lesions.
Only 7 cases of oral LS have been reported involving the gingiva. To our knowledge, this is the eigth case to be reported with gingival involvement and the first case to be reported with bilateral involvement of buccal mucosa and gingiva.
硬化性苔藓是一种病因不明的慢性黏膜皮肤炎症性疾病。仅累及口腔黏膜的硬化性苔藓患病率极低，仅有26例经组织学证实的口腔硬化性苔藓病例报道。
一名60岁男性因口腔白色病变就诊于我院，除此之外无任何症状，也无皮肤或肛门生殖器病变。临床检查发现双侧颊黏膜及上颌后牙龈有白色斑块及微红区域。病变的显微镜分析显示上皮萎缩伴基底细胞变性，结缔组织基质透明化，慢性炎性细胞浸润极少。Verhoeff染色显示结缔组织基质中弹性纤维稀少。基于这些组织学发现，最终诊断为硬化性苔藓。硬化性苔藓在口腔中罕见，尤其是在无同时存在的皮肤和肛门生殖器病变的情况下。
仅有7例累及牙龈的口腔硬化性苔藓病例报道。据我们所知，这是第8例报道累及牙龈的病例，也是第1例报道双侧颊黏膜和牙龈受累的病例。
