Yanagawa Youichi
Department of Traumatology and Critical Care Medicine, National Defense Medical College (NDMC), Japan.
J Emerg Trauma Shock. 2011 Jul;4(3):365-8. doi: 10.4103/0974-2700.83865.
To investigate the relationship between the duration of comatose state, severity of rhabdomyolysis and frequency of peripheral nerve injury (PNI) in patients following psychotropic drug overdose.
Medical charts were retrospectively reviewed for 41 patients admitted for disturbance of consciousness induced by an overdose of psychotropic drugs with rhabdomyolysis between October 2004 and February 2010. Subjects were divided into PNI group (n=9) and non-PNI control group (n=32).
Mean interval between drug ingestion and arrival, frequency of pressure ulcers, CK level at the time of patient's arrival and maximum CK level during hospitalization, duration of hospitalization and morbidity rate were all significantly higher in the PNI group than in the control group.
In patients with a psychotropic drug overdose leading to a comatose state, the longer the comatose state, the more likely that pressure ulcers and PNI will occur.
研究精神药物过量患者昏迷状态持续时间、横纹肌溶解严重程度与周围神经损伤（PNI）发生率之间的关系。
回顾性分析2004年10月至2010年2月期间因精神药物过量致意识障碍合并横纹肌溶解而入院的41例患者的病历。将患者分为PNI组（n = 9）和非PNI对照组（n = 32）。
PNI组药物摄入至入院的平均间隔时间、压疮发生率、患者入院时的肌酸激酶（CK）水平及住院期间的最高CK水平、住院时间和发病率均显著高于对照组。
在因精神药物过量导致昏迷状态的患者中，昏迷状态持续时间越长，发生压疮和PNI的可能性越大。
