Hashmi Mubashira, Wasay Mohammad
Department of Medicine, Section of Neurology, Aga Khan University and Hospital, Stadium Road, Karachi, Pakistan.
J Emerg Trauma Shock. 2011 Jul;4(3):389-94. doi: 10.4103/0974-2700.83870.
Cerebral venous sinus thrombosis in children is increasingly recognized as diagnostic tools and clinical awareness has improved. It is a multifactorial disease where prothrombotic risk factors and predisposing clinical conditions usually in combination constitute the underlying etiology. Clinical features range from headache, seizures to comatose state. Although symptomatic treatment involving control of infections, seizures and intracranial hypertension is uniform, use of anticoagulation and local thrombolytic therapy is still controversial. Morbidity and mortality can be significant and long-term neurological sequelae include developmental delay, sensorimotor and visual deficits and epilepsy.
儿童脑静脉窦血栓形成越来越多地被认识到,诊断工具有所改进,临床意识也有所提高。它是一种多因素疾病,血栓形成前危险因素和易感临床状况通常共同构成潜在病因。临床特征包括从头痛、癫痫发作到昏迷状态。尽管涉及控制感染、癫痫发作和颅内高压的对症治疗是一致的,但抗凝和局部溶栓治疗的使用仍存在争议。发病率和死亡率可能很高,长期神经后遗症包括发育迟缓、感觉运动和视觉缺陷以及癫痫。