病灶内注射普萘洛尔治疗眼周毛细血管瘤的评估
Evaluation of intralesional propranolol for periocular capillary hemangioma.
作者信息
Awadein Ahmed, Fakhry Mohamed A
机构信息
Cairo University Faculty of Medicine, Cairo, Egypt.
出版信息
Clin Ophthalmol. 2011;5:1135-40. doi: 10.2147/OPTH.S22909. Epub 2011 Aug 15.
BACKGROUND
The purpose of this study was to evaluate the use of intralesional propranolol injection in the management of periocular capillary hemangioma.
METHODS
A prospective study was performed in 22 consecutive patients with periocular hemangioma. Twelve patients underwent intralesional propranolol injection and ten patients underwent intralesional triamcinolone injection. The size of the lesion was measured serially every week during the first month, every 2 weeks for the second month, and then monthly for another 2 months. The refractive error and degree of ptosis if present were measured before injection and at the end of the study.
RESULTS
There was reduction in the size of hemangioma, astigmatic error, and degree of ptosis in both groups. The difference in outcome between both groups was not statistically significant. Rebound growth occurred in 25% of the propranolol group and 30% of the steroid group but responded to reinjection. No adverse effects were reported during or after intralesional propranolol injection.
CONCLUSION
Intralesional propranolol injection is an alternative and effective method for treatment of infantile periocular hemangioma.
背景
本研究的目的是评估病灶内注射普萘洛尔治疗眼周毛细血管瘤的效果。
方法
对22例连续性眼周血管瘤患者进行前瞻性研究。12例患者接受病灶内注射普萘洛尔，10例患者接受病灶内注射曲安奈德。在第一个月每周连续测量病灶大小，第二个月每2周测量一次，之后2个月每月测量一次。在注射前及研究结束时测量屈光不正及上睑下垂程度（若存在）。
结果
两组患者的血管瘤大小、散光误差及上睑下垂程度均减小。两组结果差异无统计学意义。普萘洛尔组25%、类固醇组30%出现复发，但再次注射有效。病灶内注射普萘洛尔期间及之后均未报告不良反应。
结论
病灶内注射普萘洛尔是治疗婴幼儿眼周血管瘤的一种有效替代方法。
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