Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
J Pharmacol Sci. 2011;116(3):316-20.
In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABA(A)-benzodiazepine receptor complex, but not 5-HT(1A) receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.
在本研究中，我们考察了汉方药（和汉药）一贯煎（YKS）对群居和独居小鼠戊巴比妥诱导睡眠的影响。独居小鼠的睡眠时间比群居小鼠短。YKS（300mg/kg，po）延长了独居小鼠戊巴比妥诱导的睡眠时间，而对群居小鼠戊巴比妥睡眠没有影响。YKS 对睡眠时间的延长作用被荷包牡丹碱（3mg/kg，ip）和氟马西尼（3mg/kg，ip）逆转，但WAY100635 没有逆转。这些发现表明，YKS 对社交隔离引起的戊巴比妥睡眠时间减少的逆转作用涉及 GABA(A)-苯二氮䓬受体复合物，而不是 5-HT(1A)受体。
