Sharma Tarun Kumar, Parchwani Hundal, Kaushik Girdhar Gopal, Shankar Vijay, Dahiya Kiran, Ghalaut Veena Singh, Sharma Neha
Department of Biochemistry, Pt. B.D. Sharma, University of Health Sciences, P.G.I.M.S., Rohtak, Haryana 124001, India.
Clin Lab. 2011;57(7-8):517-22.
High levels of glycated hemoglobin (HbA(1c)) have been associated with Coronary Vascular Diseases (CVD) in diabetic patients. Recent studies have reported no association between elevated glycated hemoglobin (HbA(1c)) and incident cardiovascular disease (CVD) among women without diabetes. There are many controversial studies on topics such as "Glycated hemoglobin levels (HbA(1c)) have been associated with cardiovascular diseases (CVD) in the non-diabetic patients". Therefore, we planned this study.
The present study was conducted on 50 age matched controls and 50 clinically diagnosed non-diabetic CVD patients of either gender. The study included 50 patients with myocardial infarction (MI) admitted to the ICCU ward of J.L.N. Medical College and Hospital, Ajmer (Rajasthan). The following information was recorded from admission sheets of non-diabetic CVD patients of either gender: history of diabetes, hypertension, and cigarette smoking; demographic indices; coronary heart disease and diabetes mellitus treatment; serum cholesterol; serum triglycerides (TG); high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C); fasting and non-fasting blood glucose levels and Glycated haemoglobin levels (HbA(1c)). Glycosylated hemoglobin (HbA(1c)) was measured by latex agglutination inhibition assay.
The HbA(1c) levels in healthy controls (n = 50) and non-diabetic CVD subjects (n = 50) observed were 4.32 +/- 0.34% and 5.80 +/- 0.20%, respectively. HbA(1c) levels in these subjects were significantly higher than controls (p < 0.001). The HbA(1c) levels in non-diabetic CVD patients are higher in comparison to controls.
糖尿病患者中，高水平的糖化血红蛋白（HbA₁c）与冠状动脉血管疾病（CVD）相关。近期研究报道，在无糖尿病的女性中，糖化血红蛋白（HbA₁c）升高与心血管疾病（CVD）发病之间无关联。关于“糖化血红蛋白水平（HbA₁c）与非糖尿病患者的心血管疾病（CVD）相关”等主题存在许多有争议的研究。因此，我们开展了本研究。
本研究对50名年龄匹配的对照者以及50名临床诊断的非糖尿病性CVD患者（男女不限）进行。研究纳入了50名入住阿杰梅尔（拉贾斯坦邦）J.L.N.医学院医院ICCU病房的心肌梗死（MI）患者。从男女非糖尿病性CVD患者的入院记录中记录以下信息：糖尿病、高血压和吸烟史；人口统计学指标；冠心病和糖尿病治疗情况；血清胆固醇；血清甘油三酯（TG）；高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）；空腹和非空腹血糖水平以及糖化血红蛋白水平（HbA₁c）。采用乳胶凝集抑制试验测定糖化血红蛋白（HbA₁c）。
观察到健康对照者（n = 50）和非糖尿病性CVD受试者（n = 50）的HbA₁c水平分别为4.32±0.34%和5.80±0.20%。这些受试者的HbA₁c水平显著高于对照者（p < 0.001）。与对照者相比，非糖尿病性CVD患者的HbA₁c水平更高。
