Pejda Slavica, Alajbeg Ivan, Alajbeg Iva
Zavod za oralnu medicinu, Stomatologki fakultet Sveunilita u Zagrebu.
Lijec Vjesn. 2011 May-Jun;133(5-6):180-6.
The aims were to obtain epidemiological and etiological data on xerostomia in cross section of Croatian population, and to evaluate adherence to "American European Consensus Group" (AECG) classification criteria for Sjögren's syndrome (SSj), in order to identify possible need for improvements in differential diagnosis of xerostomia. A retrospective study among patients seen at the Department of oral medicine for complaints of dry mouth was performed. Three hundred and ninety-five patients met inclusion criteria. A data base was formed, comprising epidemiological, clinical and sialometric data, immunological, scintigraphic, ultrasonographic and histopathological findings of salivary glands, coupled with drug intake listings. Descriptive statistics were used for data analysis. Objective salivary hypofunction was found in 74% of our patients. The most common probable cause of xerostomia was side effect of pharmacotherapy. SSj was diagnosed in 6.7% of patients with xerostomia, whereas in another 8% of patients Sjögren's syndrome was strongly suspected, but labial gland biopsy wasn't performed, indicating a lack of adherence to AECG criteria for SSj diagnosis. Application of AECG criteria in differential diagnosis of patients with dry mouth is mandatory, as well as educating general practitioners, dentists and patients on xerogenic side effects of pharmacotherapy.
本研究旨在获取克罗地亚人群中口干症的流行病学和病因学数据，并评估对“美国-欧洲共识小组”（AECG）干燥综合征（SSj）分类标准的遵循情况，以确定口干症鉴别诊断中可能需要改进的地方。对口腔医学科因口干主诉就诊的患者进行了一项回顾性研究。395名患者符合纳入标准。建立了一个数据库，包括流行病学、临床和唾液流量测定数据、唾液腺的免疫学、闪烁扫描、超声和组织病理学检查结果，以及药物摄入清单。采用描述性统计进行数据分析。我们发现74%的患者存在客观的唾液腺功能减退。口干症最常见的可能原因是药物治疗的副作用。在口干症患者中，6.7%被诊断为SSj，另有8%的患者高度怀疑患有干燥综合征，但未进行唇腺活检，这表明在SSj诊断中未遵循AECG标准。在口干症患者的鉴别诊断中必须应用AECG标准，同时要对全科医生、牙医和患者进行药物治疗致口干副作用方面的教育。
