The Border Biomedical Research Center and Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA.
Trends Endocrinol Metab. 2011 Dec;22(12):481-90. doi: 10.1016/j.tem.2011.08.001. Epub 2011 Aug 31.
FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which is largely attributed to differences in the FK1 domain and the proline-rich loop. FKBP51 and FKBP52 have emerged as likely contributors to a variety of hormone-dependent diseases, including stress-related diseases, immune function, reproductive functions and a variety of cancers. In addition, recent studies have implicated FKBP51 and FKBP52 in Alzheimer's disease and other protein aggregation disorders. This review summarizes our current understanding of FKBP51 and FKBP52 interactions within the receptor-chaperone complex, their contributions to health and disease, and their potential as therapeutic targets for the treatment of these diseases.
FKBP51 和 FKBP52 是类固醇激素受体信号转导的多样化调节剂，包括受体成熟、激素结合和核转位。尽管结构相似，但它们在功能上是不同的，这主要归因于 FK1 结构域和富含脯氨酸的环的差异。FKBP51 和 FKBP52 已成为多种激素依赖性疾病的可能贡献者，包括与应激相关的疾病、免疫功能、生殖功能和多种癌症。此外，最近的研究表明 FKBP51 和 FKBP52 与阿尔茨海默病和其他蛋白质聚集障碍有关。本综述总结了我们目前对受体伴侣复合物中 FKBP51 和 FKBP52 相互作用的理解，它们对健康和疾病的贡献，以及它们作为治疗这些疾病的治疗靶点的潜力。
