National Institute for Cancer Research, Largo R. Benzi, 16132 Genova, Italy.
Trends Immunol. 2011 Nov;32(11):517-23. doi: 10.1016/j.it.2011.06.013. Epub 2011 Aug 31.
During the early phases of pregnancy, natural killer (NK) cells are the predominant lymphoid cells in the human decidua. Here, rather than act as killers and/or drivers of inflammation, NK cells contribute to tissue building and remodeling and formation of new vessels due to the release of interleukin-8, vascular endothelial growth factor, stromal cell-derived factor-1 and interferon gamma-inducible protein-10. Here, we propose that the interaction of NK cells with CD14(+) myelomonocytic cells to promote induction of T regulatory cells plays a pivotal role in immunosuppression and tolerance towards the fetus allograft. Importantly, CD34(+) hematopoietic precursors are present in human decidua and may give rise to decidual NK cells. Defects in decidual NK cell generation, or in appropriate functional interactions with other cell types, could have major consequences for successful pregnancy.
在妊娠早期，自然杀伤 (NK) 细胞是人类蜕膜中主要的淋巴样细胞。在这里，NK 细胞释放白细胞介素-8、血管内皮生长因子、基质细胞衍生因子-1 和干扰素 γ 诱导蛋白-10，促进组织构建和重塑以及新血管的形成，而不是作为杀手和/或炎症驱动因素。在这里，我们提出 NK 细胞与 CD14(+)髓样单核细胞相互作用，以促进诱导 T 调节细胞，在对胎儿同种异体移植物的免疫抑制和耐受中发挥关键作用。重要的是，人类蜕膜中存在 CD34(+)造血前体细胞，并且可能产生蜕膜 NK 细胞。蜕膜 NK 细胞生成缺陷，或与其他细胞类型的适当功能相互作用，可能对成功妊娠产生重大影响。
