Department of Psychosomatic Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):183-8. doi: 10.1016/j.pnpbp.2011.08.014. Epub 2011 Aug 25.
Sertraline is one of the most commonly used antidepressants in clinic. Although it is well accepted that sertraline exerts its action through inhibition of the reuptake of serotonin at presynaptic site in the brain, its effect on the neural stem cells (NSCs) has not been well elucidated. In this study, we utilized NSCs separated from the hippocampus of fetal rat to investigate the effect of sertraline on the proliferation and differentiation of NSCs. The study demonstrated that sertraline had no effect on NSCs proliferation but it significantly promoted NSCs to differentiate into serotoninergic neurons other than glia cells. Furthermore, we found that sertraline protected NSCs against the lipopolysaccharide-induced cellular damage. These data indicate that sertraline can promote neurogenesis and protect the viability of neural stem cells.
舍曲林是临床中最常用的抗抑郁药之一。虽然公认舍曲林通过抑制大脑突触前部位 5-羟色胺的再摄取发挥作用，但它对神经干细胞（NSCs）的影响尚未得到充分阐明。在这项研究中，我们利用从胎鼠海马中分离的 NSCs 来研究舍曲林对 NSCs 增殖和分化的影响。研究表明，舍曲林对 NSCs 增殖没有影响，但它显著促进 NSCs 分化为 5-羟色胺能神经元，而不是神经胶质细胞。此外，我们发现舍曲林可以保护 NSCs 免受脂多糖诱导的细胞损伤。这些数据表明舍曲林可以促进神经发生并保护神经干细胞的活力。
