Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
Biol Psychol. 2011 Dec;88(2-3):270-9. doi: 10.1016/j.biopsycho.2011.08.012. Epub 2011 Sep 1.
We investigated whether chronic job stress, i.e., effort-reward imbalance (ERI) and overcommitment is associated with cellular immunity among 190 male and 157 female white-collar daytime employees (mean age 38; range 22-69 years). Participants provided a blood sample for the measurement of circulating immune (natural killer (NK), B, and T) cell counts and NK cell cytotoxicity (NKCC) and completed a questionnaire survey during April to June 2002. Stepwise multiple linear regression analyses revealed that NK cells were associated with effort (β=-.230; p=.013), reward (β=.169; p=.047), and ERI (β=-.182; p=.047) scores but not with overcommitment in men; reward score was positively associated with NKCC (β=.167; p=.049) and inversely associated with B cells (β=-.181; p=.030). No significant associations were found in women. Although the picture remains less clear in women, our findings suggest a potential immunological pathway linking adverse working conditions and stress-related disorders in men.
我们调查了慢性工作压力（即努力-回报失衡（ERI）和过度投入）是否与 190 名男性和 157 名女性白领日间员工（平均年龄 38 岁；范围 22-69 岁）的细胞免疫有关。参与者提供了一份血液样本，用于测量循环免疫（自然杀伤 (NK)、B 和 T）细胞计数和 NK 细胞细胞毒性 (NKCC)，并在 2002 年 4 月至 6 月期间完成了一份问卷调查。逐步多元线性回归分析表明，NK 细胞与努力（β=-.230；p=.013）、回报（β=.169；p=.047）和 ERI（β=-.182；p=.047）得分有关，但与男性的过度投入无关；回报得分与 NKCC 呈正相关（β=.167；p=.049），与 B 细胞呈负相关（β=-.181；p=.030）。在女性中没有发现显著的关联。尽管女性的情况仍然不太清楚，但我们的研究结果表明，在男性中，一种潜在的免疫途径可能将不良工作条件和与压力相关的疾病联系起来。
