Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Endocrinol Metab Clin North Am. 2011 Sep;40(3):591-614, ix. doi: 10.1016/j.ecl.2011.05.002. Epub 2011 Jul 7.
The mainstay targets for hormonal prostate cancer (PCa) therapies are based on negating androgen action. Recent epidemiologic and experimental data have pinpointed the key roles of estrogens in PCa development and progression. Racial and geographic differences, as well as age-associated changes, in estrogen synthesis and metabolism contribute significantly to the etiology. This article summarizes how different estrogens/antiestrogens/estrogen mimics contribute to prostate carcinogenesis, the roles of the different mediators of estrogen in the process, and the potentials of new estrogenic/antiestrogenic compounds for prevention and treatment of PCa.
激素前列腺癌(PCa)治疗的主要靶点基于消除雄激素作用。最近的流行病学和实验数据指出了雌激素在 PCa 发展和进展中的关键作用。雌激素合成和代谢的种族和地理差异以及与年龄相关的变化,对病因有重要影响。本文总结了不同的雌激素/抗雌激素/雌激素类似物如何促进前列腺癌的发生,雌激素在这一过程中的不同介质的作用,以及新的雌激素/抗雌激素化合物在预防和治疗 PCa 方面的潜力。