Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Am J Obstet Gynecol. 2011 Dec;205(6):549.e1-7. doi: 10.1016/j.ajog.2011.06.103. Epub 2011 Jul 13.
The objective of the study was to assess the use of mean, lowest, and highest pulsatility index (PI) of the uterine arteries to screen for adverse pregnany outcome in twin pregnancies.
This was a screening study of 423 twin pregnancies. Relationship between PI at 20-22 weeks and adverse pregnancy outcome was evaluated.
Mean, lowest, and highest PI above the 95th centile were significant risk factors for preeclampsia and adverse pregnancy outcome in monochorionic and dichorionic twins. We calculated a sensitivity for preeclampsia for mean, highest, and lowest PI of 35%, 29%, and 27%, respectively.
Increased mean, lowest, and highest PI is associated with a higher risk of preeclampsia and adverse pregnancy outcome in twins. We observed the highest sensitivity and specificity by using highest PI. The high incidence of preeclampsia in twins makes it attractive to use the PI of the uterine artery for risk stratification in twins.
本研究旨在评估子宫动脉平均、最低和最高搏动指数（PI）用于筛查双胎妊娠不良妊娠结局的价值。
这是一项对 423 例双胎妊娠的筛查研究。评估了 20-22 周时 PI 与不良妊娠结局之间的关系。
高于第 95 百分位数的平均、最低和最高 PI 是单绒毛膜和双绒毛膜双胎子痫前期和不良妊娠结局的显著危险因素。我们计算了平均、最高和最低 PI 预测子痫前期的敏感性分别为 35%、29%和 27%。
平均、最低和最高 PI 的增加与双胎妊娠子痫前期和不良妊娠结局的风险增加相关。我们观察到使用最高 PI 时具有最高的敏感性和特异性。双胎妊娠中子痫前期的高发生率使得使用子宫动脉 PI 对双胎妊娠进行风险分层具有吸引力。
