Department of Plant Systems Biology, VIB, 9052 Gent, Belgium.
Trends Plant Sci. 2011 Nov;16(11):624-34. doi: 10.1016/j.tplants.2011.07.001. Epub 2011 Sep 1.
Endoreplication, also called endoreduplication, is a cell cycle variant of multicellular eukaryotes in which mitosis is skipped and cells repeatedly replicate their DNA, resulting in cellular polyploidy. In recent years, research results have shed light on the molecular mechanism of endoreplication control, but the function of this cell-cycle variant has remained elusive. However, new evidence is at last providing insight into the biological relevance of cellular polyploidy, demonstrating that endoreplication is essential for developmental processes, such as cell fate maintenance, and is a prominent response to physiological conditions, such as pathogen attack or DNA damage. Thus, endoreplication is being revealed as an important module in plant growth that contributes to the robustness of plant life.
内复制，也称为核内有丝分裂，是真核多细胞生物的一种细胞周期变异形式，其中有丝分裂被跳过，细胞反复复制其 DNA，导致细胞多倍体化。近年来，研究结果揭示了内复制控制的分子机制，但这种细胞周期变异的功能仍然难以捉摸。然而，新的证据终于为细胞多倍体的生物学相关性提供了一些见解，证明内复制对于细胞命运维持等发育过程是必不可少的，并且是对生理条件（如病原体攻击或 DNA 损伤）的显著反应。因此，内复制被揭示为植物生长的一个重要模块，有助于植物生命的稳健性。
