Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a012948. doi: 10.1101/cshperspect.a012948.
Developmentally programmed polyploidy occurs by at least four different mechanisms, two of which (endoreduplication and endomitosis) involve switching from mitotic cell cycles to endocycles by the selective loss of mitotic cyclin-dependent kinase (CDK) activity and bypassing many of the processes of mitosis. Here we review the mechanisms of endoreplication, focusing on recent results from Drosophila and mice.
发育编程性多倍体至少由四种不同的机制产生，其中两种（内复制和核内有丝分裂）涉及通过有丝分裂周期蛋白依赖性激酶（CDK）活性的选择性丧失和绕过有丝分裂的许多过程，从有丝分裂细胞周期切换到内周期。本文我们综述了内复制的机制，重点介绍了来自果蝇和小鼠的最新结果。
