Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Curr Opin Chem Biol. 2011 Oct;15(5):627-35. doi: 10.1016/j.cbpa.2011.08.009. Epub 2011 Sep 1.
Maintenance of genetic stability is of crucial importance for any form of life. Before cell division in each mammalian cell, the process of DNA replication must faithfully duplicate three billion bases with an absolute minimum of mistakes. This is complicated by the fact that DNA itself is highly reactive and is constantly attacked by endogenous and exogenous factors leading to 50,000-100,000 different damages in the DNA of human cells every day. In this mini-review we will focus on lesion bypass by DNA polymerase machines either in replication or repair, with particular focus on the repair of oxidative lesions.
维持遗传稳定性对任何形式的生命都至关重要。在每个哺乳动物细胞进行细胞分裂之前，DNA 复制过程必须以绝对最小的错误准确复制 30 亿个碱基。由于 DNA 本身具有高度反应性，并且不断受到内源性和外源性因素的攻击，导致人类细胞的 DNA 每天都会产生 5 万到 10 万个不同的损伤，这使得事情变得复杂。在这个迷你综述中，我们将重点关注 DNA 聚合酶在复制或修复过程中对损伤的绕过，特别关注氧化损伤的修复。
