氧化剂-抗氧化剂平衡与冠状动脉疾病的严重程度无关。

Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease.

机构信息

Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.

出版信息

Clin Biochem. 2011 Nov;44(16):1304-8. doi: 10.1016/j.clinbiochem.2011.08.1133. Epub 2011 Aug 25.

DOI:10.1016/j.clinbiochem.2011.08.1133

PMID:21889931

Abstract

OBJECTIVE

We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects.

DESIGN AND METHODS

Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD).

RESULTS

The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>0.05).

CONCLUSIONS

In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.

摘要

目的

我们已经测量了患有明确冠状动脉疾病（CAD）的患者的促氧化剂-抗氧化剂平衡（PAB）水平，并将其与健康受试者的浓度进行了比较。

设计和方法

根据血管造影结果，将 400 名稳定型 CAD 患者分为 CAD-和 CAD+，进一步细分为单支、双支和三支血管疾病（VD）组。

结果

健康受试者的平均 PAB 值明显低于其他组（P<0.001）。在 CAD-患者中，PAB 水平为 123.2±43.9，与 SVD、2VD 和 3VD 组相比无统计学差异（P>0.05）。在 CAD+组中，1VD、2VD 和 3VD 患者的 SVD、2VD 和 3VD 之间的 PAB 值无显著差异（P>0.05）。