Alamdari Daryoush Hamidi, Ghayour-Mobarhan Majid, Tavallaie Shima, Parizadeh Mohammad Reza, Moohebati Mohsen, Ghafoori Fahimeh, Kazemi-Bajestani Seyyed Mohammad Reza, Paletas Konstantinos, Pegiou Theodosia, Koliakos George
Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Clin Biochem. 2008 Apr;41(6):375-80. doi: 10.1016/j.clinbiochem.2007.12.008. Epub 2007 Dec 27.
Determination of the prooxidant-antioxidant balance (PAB) in patients with angiographically defined coronary artery disease (CAD+) by a modified PAB assay and presentation of PAB value as a novel cardiovascular risk factor.
For 61 patients with CAD+ and 63 healthy volunteers, the PAB were measured and its correlation was determined with anthropological and clinical parameters.
A significant increase of the PAB value was observed in patients in comparison to control group. A correlation, which is not quite significant, was noted between angiographic finding (number of diseased vessel) and the PAB values in patients. A significant positive correlation was established between the PAB value and systolic blood pressure, diastolic blood pressure, smoking, fasting blood sugar and serum urea concentration; and a significant negative correlation was established between PAB value and serum creatinine and bilirubin.
This study shows that the PAB value may be considered as a cardiovascular risk factor. Further clinical research is needed to substantiate the potency of the PAB value as a cardiovascular risk factor.
通过改良的促氧化-抗氧化平衡（PAB）检测方法，测定经血管造影确诊的冠心病患者（CAD+）的促氧化-抗氧化平衡，并将PAB值作为一种新型心血管危险因素进行呈现。
对61例CAD+患者和63名健康志愿者进行PAB检测，并确定其与人体学和临床参数的相关性。
与对照组相比，患者的PAB值显著升高。患者的血管造影结果（病变血管数量）与PAB值之间存在不太显著的相关性。PAB值与收缩压、舒张压、吸烟、空腹血糖和血清尿素浓度之间存在显著正相关；PAB值与血清肌酐和胆红素之间存在显著负相关。
本研究表明，PAB值可被视为一种心血管危险因素。需要进一步的临床研究来证实PAB值作为心血管危险因素的效力。
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