Rahsepar Amir Ali, Mirzaee Asadollah, Moodi Fatemeh, Moohebati Mohsen, Tavallaie Shima, Eshraghi Ali, Alavi Maryam-Sadat, Khorashadizadeh Fatemeh, Pourghadamyari Hossein, Paydar Roghayeh, Amini Maral, Khojasteh Roshanak, Mousavi Somayeh, Sahebi Maryam, Ghayour-Mobarhan Majid, Ferns Gordon A A
Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Cardiology. 2012;122(4):203-9. doi: 10.1159/000339273. Epub 2012 Jul 31.
We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD).
Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients.
PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = -0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05).
Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.
我们研究了冠状动脉疾病（CAD）患者体内的促氧化剂 - 抗氧化剂平衡（PAB）、抗丙二醛修饰的低密度脂蛋白（氧化型低密度脂蛋白，ox-LDL）IgG抗体与心功能指标（收缩和舒张功能）之间的关联。
选取55例确诊CAD患者，测量其血清抗ox-LDL IgG水平和PAB值，并与40例匹配的健康对照者进行比较。测定所有患者的收缩和舒张功能。
患者的PAB值显著高于对照组（p < 0.001），而两组间血清抗ox-LDL浓度无统计学差异（p = 0.821）。然而，在调整高密度脂蛋白胆固醇后，患者的抗ox-LDL水平较高（p = 0.04）。总PAB值与射血分数呈负相关（r = -0.326，p = 0.031），但两组中抗ox-LDL与射血分数的关系均非如此（p > 0.05）。
氧化应激标志物（PAB值）的血清浓度与心功能呈负相关。PAB是一个相对简单的指标，可纳入CAD患者的风险评估。抗ox-LDL IgG抗体浓度似乎不能反映由PAB评估的总氧化应激。
