Mood and Anxiety Program, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Schizophr Res. 2011 Dec;133(1-3):150-5. doi: 10.1016/j.schres.2011.08.006. Epub 2011 Sep 3.
Toxoplasma gondii (T. gondii) a widespread neurotropic parasite, has been previously associated with schizophrenia and more recently with suicidal behavior. However, no previous study has examined the association of T. gondii with suicidal behavior in schizophrenia patients. 950 individuals diagnosed with schizophrenia by SCID were recruited from the Munich area of Germany. Solid-enzyme immunoassay methods were used to measure IgG plasma antibodies to T. gondii, other neurotropic pathogens and gliadin. Logistic regression models were developed to analyze the association of T. gondii seropositivity or serointensity with history of suicidal behavior. In those younger than the median age of the sample, 38, T. gondii serointensity was associated with history of suicidal behavior (p = 0.02), while in the older patients the relationship was not significant (p = 0.21). Seropositivity was also associated with history of suicide attempt in younger patients, odds ratio 1.59 (95% CI 1.06 to 2.40), p = 0.03. Seropositivity for CMV (p = 0.22), HSV-1 (p = 0.36) and gliadin (p = 0.92) was not related to history of suicide attempt in the entire sample or any age subgroup. T. gondii serology might become, with interaction with vulnerability genes, a candidate biomarker for a subgroup of schizophrenia patients prone to attempting suicide.
刚地弓形虫（T. gondii）是一种广泛存在的神经嗜性寄生虫，先前与精神分裂症有关，最近与自杀行为有关。然而，以前没有研究检查过刚地弓形虫与精神分裂症患者自杀行为之间的关联。
通过 SCID 诊断患有精神分裂症的 950 人从德国慕尼黑地区招募。使用固相酶免疫测定方法测量针对刚地弓形虫、其他神经嗜性病原体和麦胶蛋白的 IgG 血浆抗体。开发了逻辑回归模型来分析刚地弓形虫血清阳性或血清强度与自杀行为史的关联。在年龄小于样本中位数（38 岁）的患者中，刚地弓形虫血清强度与自杀行为史相关（p=0.02），而在年龄较大的患者中，这种关系不显著（p=0.21）。在年龄较小的患者中，血清阳性也与自杀未遂史相关，优势比为 1.59（95%CI 1.06 至 2.40），p=0.03。在整个样本或任何年龄亚组中，CMV（p=0.22）、HSV-1（p=0.36）和麦胶蛋白（p=0.92）的血清阳性与自杀未遂史无关。刚地弓形虫血清学可能会与易感性基因相互作用，成为易发生自杀未遂的精神分裂症患者亚组的候选生物标志物。
