Muldoon E, Mulcahy F
St James's Hospital, Genitourinary Medicine and Infectious Diseases, Dublin, Ireland.
Int J STD AIDS. 2011 Sep;22(9):493-7. doi: 10.1258/ijsa.2011.010438.
A large outbreak of syphilis was reported in Dublin, Ireland, in 2001. The mean age of patients in 2001 was 35 years and 22.5% of patients were HIV-positive. The number of new cases decreased from 2003 on, however, new diagnoses have again increased. All positive syphilis serology results from 2007-09 were identified. Patients were included if they had a newly positive syphilis serology or, in the case of patients with previously treated syphilis, had a four-fold rise in rapid plasma reagin titre. Four hundred and thirty-nine new diagnoses of syphilis were made. The mean age of patients at diagnosis was 35.7 years (range 17-73 years). Four hundred and twelve (93.8%) cases occurred in men. Three hundred and eighty-one (86.8%) cases occurred in men who have sex with men (MSM). The estimated crude incidence rate among MSM is 378.16 per 100,000 population. Where known, 126/421 (28.7%) occurred in HIV-positive patients. Sixty-eight (15.5%) episodes of syphilis infection were diagnosed in patients who had had previously been diagnosed and treated for syphilis; 43/68 (63.2%) cases of re-infection occurred in HIV-positive patients. The rising number of syphilis diagnoses and high associated HIV co-infection rate is concerning and prevention efforts must continue to decrease the number of new syphilis cases.
2001年，爱尔兰都柏林报告了一起大规模梅毒疫情。2001年患者的平均年龄为35岁，22.5%的患者艾滋病毒呈阳性。新病例数从2003年开始减少，然而，新诊断病例数再次增加。确定了2007 - 2009年所有梅毒血清学阳性结果。如果患者梅毒血清学新呈阳性，或者对于先前接受过梅毒治疗的患者，快速血浆反应素滴度有四倍升高，则将其纳入研究。共做出439例梅毒新诊断。诊断时患者的平均年龄为35.7岁（范围17 - 73岁）。412例（93.8%）病例发生在男性中。381例（86.8%）病例发生在男男性行为者（MSM）中。MSM人群中估计的粗发病率为每10万人口378.16例。在已知情况中，126/421例（28.7%）发生在艾滋病毒阳性患者中。68例（15.5%）梅毒感染病例是在先前已被诊断和治疗过梅毒的患者中诊断出来的；43/68例（63.2%）再感染病例发生在艾滋病毒阳性患者中。梅毒诊断数量的上升以及高相关艾滋病毒合并感染率令人担忧，必须继续开展预防工作以减少新梅毒病例的数量。
