Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
Clin Infect Dis. 2011 Oct;53(7):697-710. doi: 10.1093/cid/cir523.
The objective of this review was to determine whether consistent definitions were used in published studies of bloodstream infections due to central venous catheters in patients with cancer (ie, catheter-related or catheter-associated bloodstream infections). Review of 191 studies reporting catheter-related or catheter-associated bloodstream infections in patients with cancer revealed a lack of uniformity in these definitions. We grouped definitions by type, with 39 articles failing to cite or report a definition. Definitions included those of the Centers for Disease Control and Prevention (n = 39) and the Infectious Diseases Society of America (n = 18). The criteria included in the definitions in studies were also tabulated. Clinical manifestations were frequently included. Definitions used have been highly variable; comparability of risk factors, incidence, management, and outcomes of such infections is difficult to achieve across studies. Future research should focus on development of a common definition of catheter-related and catheter-associated bloodstream infections for both adults and children with cancer.
本次综述的目的在于确定在癌症患者（即导管相关性或导管相关血流感染）的中心静脉导管相关血流感染的研究中是否使用了一致的定义。对 191 项报告癌症患者导管相关性或导管相关血流感染的研究进行综述，发现这些定义并不统一。我们根据类型对定义进行分组，有 39 篇文章未引用或报告定义。这些定义包括疾病控制和预防中心（n=39）和传染病协会（n=18）的定义。研究中纳入的标准也被制表。临床表现通常包括在内。使用的定义差异很大；很难在研究之间实现此类感染的危险因素、发生率、管理和结果的可比性。未来的研究应集中于为癌症成人和儿童开发一种共同的导管相关性和导管相关血流感染的定义。
