F-18 FDG PET 在原发性硬化性胆管炎和胆管癌患者中的应用：视觉分析和半定量分析。

The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis.

机构信息

Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.

出版信息

Clin Nucl Med. 2011 Oct;36(10):879-83. doi: 10.1097/RLU.0b013e3182291a64.

DOI:10.1097/RLU.0b013e3182291a64

PMID:21892037

Abstract

AIM

The aim of this study was to assess the value of 18F-fluorodeoxyglucose positron emission tomography (F-18 FDG PET) in patients with suspected cholangiocarcinoma (CC).

METHODS

Sixty-five patients with suspected CC were included in this retrospective study. All patients had whole-body FDG PET/CT imaging at a mean time of 100 minutes after administration of FDG injection. PET studies were analyzed using visual analysis and semiquantitative analysis. Semiquantitative analysis was performed using maximum standardized uptake value (SUVmax) and tumor-to-normal liver (T/N) ratio. Malignancy was defined using the following criteria: (1) Visual analysis; (2) SUVmax >3.9; (3) T/N >1.6. Analysis of variance test and receiver operating characteristic analysis were used in statistical analysis. P < 0.05 was considered significant.

RESULTS

Follow-up revealed 47 patients with CC. The average SUVmax in CC tumors was 8 ± 2.9 versus 3 ± 1 in benign lesions (P < 0.0001). The average T/N in malignant lesions was 3.5 ± 1.8 versus 1.3 ± 0.4 in benign lesions (P < 0.0001). Sensitivity, specificity, and accuracy for the 3 criteria were as follows: (1) 96%, 67%, and 88%; (2) 94%, 83%, and 91%; (3) 89%, 78%, and 86%.

CONCLUSION

F-18 FDG PET semiquantitative analysis using SUVmax >3.9 as criterion for malignancy could improve the diagnostic accuracy in differentiating malignant from benign lesions in patients with suspected CC.

摘要

目的

本研究旨在评估 18F-氟脱氧葡萄糖正电子发射断层扫描（F-18 FDG PET）在疑似胆管癌（CC）患者中的价值。

方法

本回顾性研究纳入了 65 例疑似 CC 的患者。所有患者均在 FDG 注射后平均 100 分钟行全身 FDG PET/CT 成像。采用视觉分析和半定量分析对 PET 研究进行分析。半定量分析采用最大标准化摄取值（SUVmax）和肿瘤与正常肝脏（T/N）比值进行。采用以下标准定义恶性肿瘤：（1）视觉分析；（2）SUVmax >3.9；（3）T/N >1.6。采用方差分析和受试者工作特征分析进行统计学分析。P < 0.05 为差异有统计学意义。

结果

随访发现 47 例患者患有 CC。CC 肿瘤的平均 SUVmax 为 8 ± 2.9，良性病变为 3 ± 1（P < 0.0001）。恶性病变的平均 T/N 为 3.5 ± 1.8，良性病变为 1.3 ± 0.4（P < 0.0001）。3 项标准的灵敏度、特异度和准确率分别为：（1）96%、67%和 88%；（2）94%、83%和 91%；（3）89%、78%和 86%。