Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Mar Drugs. 2011;9(8):1307-1318. doi: 10.3390/md9081307. Epub 2011 Jul 27.
Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M-Q (1-5). The structures of compounds 1-5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED₅₀ of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC₅₀ of 5.2 μg/mL.
对东沙环礁软珊瑚 Lobophytum durum 的化学研究导致分离出五个新的cembranolides，即 durumolide M-Q（1-5）。通过广泛的光谱分析，确定了化合物 1-5 的结构。化合物 4 对 P-388（小鼠淋巴细胞白血病）细胞系表现出细胞毒性，ED₅₀为 3.8 μg/mL。此外，化合物 5 对人巨细胞病毒显示出显著的抗病毒活性，IC₅₀为 5.2 μg/mL。
