来自硬叶软珊瑚的具有抗炎活性的前所未有的半缩酮柳珊瑚内酯。
Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral Lobophytum durum.
作者信息
Cheng Shi-Yie, Wen Zhi-Hong, Wang Shang-Kwei, Chiou Shu-Fen, Hsu Chi-Hsin, Dai Chang-Feng, Chiang Michael Y, Duh Chang-Yih
机构信息
Department of Marine Biotechnology and Resources, National Sun Yat-sen UniVersity, Kaohsiung 804, Taiwan, Republic of China.
出版信息
J Nat Prod. 2009 Jan;72(1):152-5. doi: 10.1021/np800686k.
PMID:19177635
Abstract
Chemical investigations of the soft coral Lobophytum durum have led to the isolation of three unprecedented hemiketal cembranolides, durumhemiketalolides A-C (1-3). Full NMR spectroscopic assignments are provided for all isolated metabolites. The anti-inflammatory activities of 1-3 were evaluated in vitro.
摘要
对软珊瑚硬叶肉芝软珊瑚进行的化学研究，已分离出三种前所未有的半缩酮西松烷型二萜内酯，硬叶半缩酮内酯A - C（1 - 3）。为所有分离出的代谢产物提供了完整的核磁共振光谱归属。对1 - 3的抗炎活性进行了体外评估。
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