School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney 2052, New South Wales, Australia.
School of Biological, Earth and Environmental Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney 2052, New South Wales, Australia.
Mar Drugs. 2011;9(8):1391-1402. doi: 10.3390/md9081391. Epub 2011 Aug 12.
Surface-associated marine bacteria often produce secondary metabolites with antagonistic activities. In this study, tropodithietic acid (TDA) was identified to be responsible for the antibacterial activity of the marine epiphytic bacterium Pseudovibrio sp. D323 and related strains. Phenol was also produced by these bacteria but was not directly related to the antibacterial activity. TDA was shown to effectively inhibit a range of marine bacteria from various phylogenetic groups. However TDA-producers themselves were resistant and are likely to possess resistance mechanism preventing autoinhibition. We propose that TDA in isolate D323 and related eukaryote-associated bacteria plays a role in defending the host organism against unwanted microbial colonisation and, possibly, bacterial pathogens.
海洋附着细菌常产生具有拮抗活性的次生代谢物。在这项研究中，发现 Tropodithietic acid（TDA）是海洋附生菌 Pseudovibrio sp. D323 及其相关菌株产生抗菌活性的原因。这些细菌也产生酚，但与抗菌活性没有直接关系。TDA 被证明能有效抑制来自不同系统发育群的多种海洋细菌。然而，TDA 的产生者本身具有抗性，可能具有防止自身抑制的抗性机制。我们提出，分离株 D323 和相关真核生物相关细菌中的 TDA 可能在保护宿主免受不需要的微生物定植和可能的细菌病原体方面发挥作用。
