Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Rajakkamangalam, Kanyakumari, Tamilnadu, India.
Department of Marine Biology, Faculty of Marine Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Curr Microbiol. 2021 Jul;78(7):2522-2533. doi: 10.1007/s00284-021-02535-4. Epub 2021 May 26.
Symbiotic marine bacteria have a pivotal role in drug discovery due to the synthesis of diverse biologically potential compounds. The marine bacterial phyla proteobacteria, actinobacteria and firmicutes are commonly associated with marine macro organisms and frequently reported as dominant bioactive compound producers. They can produce biologically active compounds that possess antimicrobial, antiviral, antitumor, antibiofilm and antifouling properties. Synthesis of these bioactive compounds is controlled by a set of genes of their genomes that is known as biosynthesis gene clusters (BGCs). The development in the field of biotechnology and bioinformatics has uncovered the potential BGCs of the bacterial genome and its functions. Now-a-days researchers have focused their attention on the identification of potential BGCs for the discovery of novel bioactive compounds using advanced technology. This review highlights the marine bacterial symbionts and their BGCs which are responsible for the synthesis of bioactive compounds.
共生海洋细菌在药物发现中起着关键作用，因为它们能够合成多种具有生物潜力的化合物。海洋细菌门变形菌门、放线菌门和厚壁菌门通常与海洋大型生物有关，并且经常被报道为主要的生物活性化合物产生菌。它们可以产生具有抗菌、抗病毒、抗肿瘤、抗生物膜和防污特性的生物活性化合物。这些生物活性化合物的合成受其基因组中一组被称为生物合成基因簇（BGCs）的基因控制。生物技术和生物信息学领域的发展揭示了细菌基因组及其功能的潜在 BGCs。如今，研究人员已经将注意力集中在利用先进技术发现新型生物活性化合物的潜在 BGCs 的鉴定上。本文综述了海洋细菌共生体及其 BGCs 负责合成生物活性化合物的情况。
