Kennard Lucinda, Thanabalasundaram Gopiga, Tailor Hiteshkumar D, Khan Wasim S
Foundation Training Department, East of England NHS Deanery, Cambridge, CB21 5XE, UK.
Open Orthop J. 2011;5(Suppl 2):249-52. doi: 10.2174/1874325001105010249. Epub 2011 Jul 28.
One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.
肌肉骨骼干细胞研究中较少受到关注的一个领域是供体年龄对干细胞质量的影响。退行性骨科疾病的患病率很高，老年人群可能会从干细胞疗法中受益匪浅。有许多已知的生长因子参与控制和影响干细胞生长，这些生长因子也与细胞衰老有关。其中，在老年供体的间充质干细胞中发现其表达发生了改变。还必须考虑这些在细胞周期和肿瘤抑制中也起作用的机制。
